Publications

Selected Recent Publications (by topic)

Fatty acid synthesis

• Maier T, Leibundgut M, Boehringer D, Ban N. (2010)
  Structure and function of eukaryotic fatty acid synthases.
  Q Rev Biophys. 43(3):373-422 Pubmed
• Maier T, Leibundgut M, and Ban N (2008)
  The Crystal Structure of a Mammalian Fatty Acid Synthase.
  Science 321(5894):1315-22 Pubmed Comment
• Leibundgut M, Jenni S, Frick C, Ban N. (2007)
  Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase.
  Science 316(5822):288-290 Pubmed
• Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolásek B, Ban N. (2007)
  Structure of Fungal Fatty Acid Synthase and Implications for Iterative Substrate Shuttling.
  Science 316:(5822):254-261. Pubmed
• Maier T, Jenni S, and Ban N. (2006)
  Architecture of mammalian fatty acid synthase at 4.5 Å resolution.
  Science 311(5765):1258-62 Pubmed Comment Comment
• Jenni S, Leibundgut M, Maier T and Ban N. (2006)
  Architecture of a fungal fatty acid synthase at 5 Å resolution.
  Science 311(5765):1263-7 Pubmed Comment Comment

Protein synthesis

• Greber BJ, Boehringer D, Godinic-Mikulcic V, Crnkovic A, Ibba M, Weygand-Durasevic I, Ban N. (2012)
  Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 and Implications for Ribosome Evolution.
  J Mol Biol. 2012 Jan 27. [Epub ahead of print] Pubmed
• Klinge S, Voigts-Hoffmann F, Leibundgut M, Arpagaus S, Ban N. (2011)
  Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6.
  Science 334(6058):941-948, Published Online November 3 2011Pubmed
• Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, Ban N. (2011)
  The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor.
  Science 331(6019):881-886 Pubmed
• Rabl J, Leibundgut M, Ataide SF, Haag A, Ban N. (2010)
  Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1.
  Science 331(6018):730-6 Pubmed
• Estrozi LF, Boehringer D, Shan SO, Ban N, Schaffitzel C. (2010)
  Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor.
  Nat Struct Mol Biol. 18(1):88-90 Pubmed
• Bingel-Erlenmeyer R, Kohler R, Kramer G, Sandikci A, Antolić S, Maier T, Schaffitzel C, Wiedmann B, Bukau B, Ban N. (2008)
  A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing.
  Nature 452(7183):108-11 Pubmed
• Schaffitzel C, Oswald M, Berger I, Ishikawa T, Abrahams JP, Koerten HK, Koning RI and Ban N. (2006)
  Structure of the E. coli signal recognition particle bound to a translating ribosome.
  Nature 444(7118):503-6 Pubmed
• Ferbitz L, Maier T, Patzelt H, Bukau B, Deuerling E and Ban N. (2004)
  Trigger Factor in Complex with the Ribosome forms a Molecular Cradle for Nascent Proteins.
  Nature 431(7008):590-6 Pubmed Comment
• Kramer, G., Rauch, T., Rist, W., Vorderwulbecke, S., Patzelt, H., Schulze-Specking, A., Ban, N., Deuerling, E., Bukau, B. (2002).
  L23 protein functions as a chaperone docking site on the ribosome.
  Nature 419(6903):171-4 Pubmed Comment
• Ban, N., Nissen, P., Hansen, J., Moore, P. B., Steitz, T. A. (2000)
  The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution.
  Science 289(5481):905-920. Pubmed Comment
• Nissen, P., Hansen, J., Ban, N., Moore, P. B., Steitz, T. A. (2000)
  The structural basis of ribosome activity in peptide bond synthesis.
  Science 289(5481):920-930 Pubmed Comment

Large Assemblies

• Mueller M, Ban N.
  Enhanced SnapShot: Pore-Forming Toxins.
  Cell 2010 142(2):334-334 Pubmed
• Mueller M, Grauschopf U, Maier T, Glockshuber R, Ban N. (2009)
  The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism.
  Nature 459(7247):726-30 Pubmed
• Sutter M, Boehringer D, Gutmann S, Günther S, Prangishvili D, Loessner MJ, Stetter KO, Weber-Ban E, Ban N. (2008)
  Structural basis of enzyme encapsulation into a bacterial nanocompartment.
  Nat Struct Mol Biol. 15(9):39–947 Pubmed
• Thore S, Leibundgut M, Ban N. (2006)
  Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand.
  Science 312(5777):1208-11 Pubmed
• Gutmann, S., Haebel, P., Metzinger, L., Sutter, M., Felden, B. and Ban, N. (2003)
  Crystal Structure of the tRNA domain of transfer messenger RNA in complex with SmpB.
  Nature 424(6949):699-703 Pubmed

Chronological Publication Record

2012

• Boehringer D, O'Farrell HC, Rife JP, Ban N. (2012)
  Structural insights into methyltransferase KsgA function in 30S ribosomal subunit biogenesis.
  J Biol Chem. 2012 Feb 3. [Epub ahead of print] Pubmed
• Greber BJ, Boehringer D, Godinic-Mikulcic V, Crnkovic A, Ibba M, Weygand-Durasevic I, Ban N. (2012)
  Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 and Implications for Ribosome Evolution.
  J Mol Biol. 2012 Jan 27. [Epub ahead of print] Pubmed

2011

• Klinge S, Voigts-Hoffmann F, Leibundgut M, Arpagaus S, Ban N. (2011)
  Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6.
  Science 334(6058):941-948, Published Online November 3 2011Pubmed
• Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, Ban N. (2011)
  The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor.
  Science 331(6019):881-886 Pubmed

2010

• Rabl J, Leibundgut M, Ataide SF, Haag A, Ban N.
  Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1.
  Science 331(6018):730-6 Pubmed
• Estrozi LF, Boehringer D, Shan SO, Ban N, Schaffitzel C.
  Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor.
  Nat Struct Mol Biol. 18(1):88-90 Pubmed
• Maier T, Leibundgut M, Boehringer D, Ban N
  Structure and function of eukaryotic fatty acid synthases.
  Q Rev Biophys. 2010 Aug; 43(3):373-422. Pubmed
• Mueller M, Ban N.
  Enhanced SnapShot: Pore-Forming Toxins.
  Cell 2010 142(2):334-334 Pubmed
• Ban N, Egelman E. (2010)
  Structure and function of large cellular assemblies.
  Curr Opin Struct Biol. 2010 Mar 9 [Epub ahead of print] Pubmed

2009

• Jaric J, Bilokapic S, Lesjak S, Crnkovic A, Ban N, Weygand-Durasevic I.
  Identification of amino acids in N-terminal domain of atypical methanogenic-type seryl-tRNA synthetase critical for tRNA recognition
  J Biol Chem. 2009 Sep 4. [Epub ahead of print] Pubmed
• Kramer G, Boehringer D, Ban N, Bukau B.
  The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins.
  Nat Struct Mol Biol. 16(6):589-97. Pubmed
• Kohler R, Boehringer D, Greber B, Bingel-Erlenmeyer R, Collinson I, Schaffitzel C, Ban N.
  YidC and Oxa1 form dimeric insertion pores on the translating ribosome.
  Mol Cell 34(3):344-53 Pubmed
• Mueller M, Grauschopf U, Maier T, Glockshuber R, Ban N.
  The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism.
  Nature 2009 May 6 [Epub ahead of print] Pubmed
• Zhang X, Schaffitzel C, Ban N, Shan SO.
  Multiple conformational switches in a GTPase complex control co-translational protein targeting.
  Proc Natl Acad Sci U S A. 2009 Jan 27. [Epub ahead of print]
• Jenni S, Ban N.
  Imperfect pseudo-merohedral twinning in crystals of fungal fatty acid synthase.
  Acta Crystallogr D Biol Crystallogr. 65(Pt 2):101-11. Epub 2009 Jan 20.

2008

• Leibundgut M, Maier T, Jenni S, Ban N.
  The multienzyme architecture of eukaryotic fatty acid synthases.
  Curr Opin Struct Biol. 18(6):714-25
• Jiang L, Schaffitzel C, Bingel-Erlenmeyer R, Ban N, Korber P, Koning RI, de Geus DC, Plaisier JR, Abrahams JP.
  Recycling of Aborted Ribosomal 50S Subunit-Nascent Chain-tRNA Complexes by the Heat Shock Protein Hsp15.
  J Mol Biol 2008 Nov 5. [Epub ahead of print]
• Maier T, Leibundgut M, and Ban N
  The Crystal Structure of a Mammalian Fatty Acid Synthase.
  Science 321(5894):1315-22
• Sutter M, Boehringer D, Gutmann S, Günther S, Prangishvili D, Loessner MJ, Stetter KO, Weber-Ban E, Ban N.
  Structural basis of enzyme encapsulation into a bacterial nanocompartment.
  Nat Struct Mol Biol. 15(9): 939-947
• Thore S, Frick C, Ban N.
  Structural basis of thiamine pyrophosphate analogues binding to the eukaryotic riboswitch.
  J Am Chem Soc. 130(26): 8116-7
• Merz F, Boehringer D, Schaffitzel C, Preissler S, Hoffmann A, Maier T, Rutkowska A, Lozza J, Ban N, Bukau B, Deuerling E.
  Molecular mechanism and structure of Trigger Factor bound to the translating ribosome.
  EMBO J. 27(11): 1622-32
• Bilokapic S, Rokov Plavec J, Ban N, Weygand-Durasevic I.
  Structural flexibility of the methanogenic-type seryl-tRNA synthetase active site and its implication for specific substrate recognition.
  FEBS J. 275(11): 2831-44
• Bingel-Erlenmeyer R, Kohler R, Kramer G, Sandikci A, Antolić S, Maier T, Schaffitzel C, Wiedmann B, Bukau B, Ban N.
  A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing.
  Nature 452(7183): 108-11

2007:

• Rutkowska A, Mayer MP, Hoffmann A, Merz F, Zachmann-Brand B,
  Schaffitzel C, Ban N, Deuerling E, Bukau B
  Dynamics of trigger factor interaction with translating ribosomes.
  J Biol Chem. 283(7): 4124-32
• Mueller M, Jenni S, Ban N
  Strategies for crystallization and structure determination of very large macromolecular assemblies.
  Curr Opin Struct Biol 17(5): 572-9.
• Boehringer D, Ban N
  Trapping the ribosome to control gene expression
  Cell 130(6): 983-5.
• Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolásek B, Ban N
  Structure of Fungal Fatty Acid Synthase and Implications for Iterative Substrate Shuttling
  Science 316: 254-261.
• Leibundgut M, Jenni S, Frick C, Ban N
  Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase
  Science 316: 288-290.
• Schaffitzel C, Ban N
  Generation of ribosome nascent chain complexes for structural and functional studies.
  J Struct Biol. 158(3): 463-71.

2006:

• Schaffitzel C, Oswald M, Berger I, Ishikawa T, Abrahams JP, Koerten HK, Koning RI, Ban N
  Structure of the E. coli signal recognition particle bound to a translating ribosome.
  Nature 444: 503-506.
• Bilokapic S, Maier T, Ahel D, Gruic-Sovulj I, Soll D, Weygand-Durasevic I, Ban N
  Structure of the unusual seryl-tRNA synthetase reveals a distinct zinc-dependent mode of substrate recognition.
  EMBO J. 25(11):2498-509.
• Thore S, Leibundgut M, Ban N
  Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand.
  Science. 312(5777): 1208-11.
• Mitra K, Schaffitzel C, Fabiola F, Chapman MS, Ban N, Frank J
  Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements.
  Mol Cell. 22(4): 533-43.
• Jenni S, Leibundgut M, Maier T, Ban N
  Architecture of a fungal fatty acid synthase at 5 Å resolution.
  Science. 311(5765): 1263-7.
• Maier T, Jenni S, Ban N
  Architecture of mammalian fatty acid synthase at 4.5 Å resolution.
  Science. 311(5765): 1258-62.

2005:

• Mitra K*, Schaffitzel C*, Shaikh T, Tama F, Jenni S, Brooks CL, Ban N & Frank J
  Structure of the E. coli protein-conducting channel bound to a translating ribosome.
  Nature. 438(7066): 318-24.
  *) contributed equally
• Maier T, Ferbitz L, Deuerling E, Ban N
  A cradle for new proteins: trigger factor at the ribosome.
  Curr Opin Struct Biol. 15(2): 204-12.
• Henrichs T, Mikhaleva N, Conz C, Deuerling E, Boyd D, Zelazny A, Bibi E, Ban N, Ehrmann M
  Target-directed proteolysis at the ribosome.
  Proc Natl Acad Sci U S A. 102(12): 4246-51.
• Leibundgut M, Frick C, Thanbichler M, Bock A, Ban N
  Selenocysteine tRNA-specific elongation factor SelB is a structural chimaera of elongation and initiation factors.
  EMBO J., 24(1): 11-22.

2004:

• Pfister P, Jenni S, Poehlsgaard J, Thomas A, Douthwaite S, Ban N, Bottger EC
  The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059.
  J Mol Biol., 342(5): 1569-81.
• Ferbitz L, Maier T, Patzelt H, Bukau B, Deuerling E and Ban N
  Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.
  Nature, 431(7008): 590-6.
• Haebel PW, Gutmann S, Ban N
  Dial tm for rescue: tmRNA engages ribosomes stalled on defective mRNAs.
  Curr Opin Struct Biol., 14(1): 58-65.
• Walser PJ, Haebel PW, Kunzler M, Sargent D, Kues U, Aebi M, Ban N
  Structure and functional analysis of the fungal galectin CGL2.
  Structure (Camb)., 12(4): 689-702.

2003:

• Abrahams JP and Ban N
  X-ray crystallographic structure determination of large asymmetric macromolecular assemblies.
  Methods Enzymol., 374: 163-88.
• Berger P, Schaffitzel C, Berger I, Ban N, Suter U
  Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module.
  Proc Natl Acad Sci USA, 100(21): 12177-82.
• Gutmann S, Haebel P, Metzinger L, Sutter M, Felden B and Ban N
  Crystal Structure of the tRNA domain of transfer messenger RNA in complex with SmpB.
  Nature, 424(6949): 699-703.
• Schaffitzel C and Ban N
  The Ribosome, high resolution structure and function.
  Encyclopedia of Molecular Cell Biology and Molecular Medicine, in press.
• Jenni S and Ban N
  The chemistry of protein synthesis and voyage through the ribosomal tunnel.
  Current Opinion in Structural Biology, 13: 212-9.

2002:

• Kramer G, Rauch T, Rist W, Vorderwulbecke S, Patzelt H, Schulze-Specking A, Ban N, Deuerling E, Bukau B
  L23 protein functions as a chaperone docking site on the ribosome.
  Nature, 419(6903): 171-4.

2001:

• Hansen J, Schmeing TM, Klein DJ, Ippolito JA, Ban N, Nissen P, Freeborn B, Moore PB and Steitz TA
  Progress toward an understanding of the structure and enzymatic mechanism of the large ribosomal subunit.
  Cold Spring Harb Symp Quant Biol. 66: 33-42., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (2001).
• Nissen P, Ippolito JA, Ban N, Moore PB and Steitz TA
  RNA tertiary interactions in the large ribosomal subunit: The A-minor motif.
  Proc. Natl. Acad. Sci. USA, 98: 4899-4903.

2000 to 1996:

• Ban N, Nissen P, Hansen J, Moore PB, Steitz TA (2000)
  The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution.
  Science, 289(5481): 905-20.
• Nissen P, Hansen J, Ban N, Moore PB, Steitz TA (2000)
  The structural basis of ribosome activity in peptide bond synthesis.
  Science, 289(5481): 920-30.
• Ban N, Nissen P, Hansen J, Moore PB and Steitz TA (2000)
  Crystal structure of the large ribosomal subunit at 5 Å resolution.
  In: "Ribosome: Structure, Function, Antibiotics, and Cellular Interactions";
  Edt: Garrett R, Douthwaite SR, Liljas A, Matheson AT, Moore PB, Noller HF, American Society for Microbiology press., USA.
• Ban N, Nissen P, Hansen J, Capel M, Moore PB, Steitz TA (1999)
  Placement of protein and RNA structures into a 5 Å - resolution map of the 50S ribosomal subunit.
  Nature, 400: 841-847.
• Penczek P, Ban N, Grassucci RA, Agrawal RK and Frank J (1999)
  Haloarcula marismortui 50S subunit - complementarity of electron microscopy and X-ray crystallographic information.
  J Struct Biol. 128(1): 44-50.
• Ban N, Freeborn B, Nissen P, Penczek P, Grassucci RA, Sweet R, Frank J, Moore PB, Steitz TA (1998)
  A 9 Å resolution X-ray crystallographic map of the large ribosomal subunit.
  Cell, 93(7): 1105-1115.
• Ban N (1998)
  Structures of large macromolecular complexes: The idiotype-anti-idiotype interactions and plant satellite viruses.
  Periodicum Biologorum, 100: 1-17.
• Ban N and McPherson A (1996)
  X-ray crystallographic studies of the idiotypic cascade.
  In: "Idiotypes in Medicine - Infections, Autoimmunity & Cancer".
  Edt: Shoenfield J, Kennedy R, Ferrone S, Elsevier Pub., The Netherlands.
• Shuller DJ, Ban N, van Huystee RB, McPherson A and Poulos TL (1996)
  The crystal structure of peanut peroxidase.
  Structure, 4: 311-321.
• Ban N, Larson SB and McPherson A (1996)
  Structural comparison of the plant satellite viruses.
  Virology, 214: 571-583.
• Ban N, Day J, Wang X, Ferrone S and McPherson A (1996)
  Crystal structure of an anti-anti-idiotype shows it to be self-complementary.
  J of Mol Biol., 255: 617-627.

1995 and before:

• Ban N and McPherson A (1995)
  The structure of satellite panicum mosaic virus at 1.9 Å resolution.
  Nature - Structural Biology, 10: 882-890.
• Ban N, Escobar C, Hasel K, Day J, Greenwood A and McPherson A (1995)
  Structure of an anti-idiotypic Fab against feline peritonitis virus neutralizing antibody and a comparison with the complexed Fab.
  FASEB Journal - thematic issue Structural Immunology, 9: 107-114.
• Day J, Ban N, Patel S, Larson S and McPherson A (1994)
  Characterization of crystals of satellite panicum mosaic virus.
  J Mol Biol., 238: 849-851.
• Ban N, Escobar C, Garcia R, Hasel K, Day J, Greenwood A and McPherson A (1994)
  Crystal structure of an idiotype-anti-idiotype Fab complex.
  Proc Natl Acad Sci USA, 91: 1604-1608.
• Ban N, Escobar C, Day J, Greenwood A and McPherson A (1993)
  Preliminary crystallographic study of a complex between an Fab of a monoclonal feline peritonitis virus neutralizing antibody and its anti-idiotypic Fab.
  J Mol Biol, 234: 894-896.
• Weygand Durasevic I, Ban N, Jahn D and Söll D (1993)
  Yeast seryl-tRNA synthetase expressed in Escherichia coli recognizes bacterial serine specific t-RNAs in vivo.
  Eur. J. Biochem. 214: 869-877.
• Ban N, Escobar C, Day J, Greenwood A, Larson S and McPherson A (1991)
  Characterization of crystals of an Fab fragment of a murine monoclonal antibody.
  J Mol Biol, 222: 445-446.
• Ban N, Van Huystee RB, Day J, Greenwood A, Larson S, Esnault R, McPherson A (1991)
  Preliminary Crystallographic Study of Peanut Peroxidase.
  Acta Crystallographica B48, 109-111.