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Group Locher
 
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Locher Lab

Molecular Mechanisms of Membrane Proteins Catalyzing Active Transport and N-linked Glycosylation

Living cells and organelles are surrounded by membranes that contain a variety of embedded proteins catalyzing processes that are essential for cells to grow and maintain their activities. We investigate the structures and mechanisms of membrane proteins catalyzing transport reactions such as nutrient uptake, drug extrusion, or lipid flipping. We also study the process of N-linked protein glycosylation, catalyzed by oligosaccharyltransferase. Our goal is to assemble molecular "movies" of these essential biochemical reactions by combining high resolution protein structures, obtained by X-ray crystallography, with biochemical and biophysical studies. For a description of ongoing projects, please check out "Research."

Pictures of recent research

FiguresFront_2reduced2

Joining the Locher lab:

Highly motivated researchers who wish to join the group as postdocs, PhD or Master students should have an interest in the structure and mechanism of membrane proteins. Projects in the group range from structure determination to biochemical and biophysical studies. Please check out "Job opportunities".



 

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